Directing Group-Assisted Copper(II)-Catalyzed ortho-Carbonylation to Benzamide using 2,2-Azobisisobutyronitrile (AIBN)

作者：Khan Bhuttu; Khan Afsar Ali; Kant Ruchir; Koley Dipankar

来源：Advanced Synthesis & Catalysis, 2016, 358(23): 3753-3758.

DOI：10.1002/adsc.201600664

<jats:title>Abstract</jats:title><jats:p>An efficient copper‐catalyzed regioselective C—H bond carbonylation of benzamides has been developed using 2,2′‐azobisisobutyronitrile (AIBN) as traceless cyanating agent. The non‐toxic and readily available AIBN was used for the carbonylative cyclization of benzamides <jats:italic>via</jats:italic> copper catalysis. The method is also applicable for the regioselective cyanation of furan, benzofuran, thiophene, benzothiophene, and pyrrole carboxamide derivatives.</jats:p><jats:p><jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/png" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/adsc201600664-toc-0001-m.png"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text>
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• 出版日期2016-12