Comparative studies in vivo of free and liposomal forms of photosensitizer on a base of hydrophilic derivative of chlorin e(6)

作者：Tran Thi Hai Yen; Meerovich I G^*; Meerovich G A; Pozdeev V I; Karshieva S Sh; Orlova O L; Polozkova A P; Oborotova N A

来源：Journal of Drug Delivery Science and Technology, 2012, 22(4): 291-294.

• Chlorin e(6)
• Photodynamic therapy
• Photosensitizer
• Bioavailability
• Selectivity
• Storage stability
• Liposomes

This work presents the results of a comparative study in vivo of photosensitizer based on hydrophilic derivative of chlorin e6 upon systemic administration in commercially available aqueous solution and hposomal form. It is demonstrated that newly developed liposomal form provides more selective accumulation of photosensitizer in tumor tissue and efficiency of antitumor action, as well as achieving an enhanced storage stability in comparison to the original form.

• 出版日期2012-8