Usefulness of the "Candida score" for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: A prospective multicenter study

作者：Leon Cristobal^*; Ruiz Santana Sergio; Saavedra Pedro; Galvan Beatriz; Blanco Armando; Castro Carmen; Balasini Carina; Utande Vazquez Aranzazu; Gonzalez de Molina Francisco J; Blasco Navalproto Miguel A; Lopez Maria J; Charles Pierre Emmanuel; Martin Estrella; Adela Hernandez Viera Maria

来源：Critical Care Medicine, 2009, 37(5): 1624-1633.

DOI：10.1097/CCM.0b013e31819daa14

• algorithms
• antifungal agents/therapeutic use
• candidiasis/diagnosis
• critical illness
• fungemia/prevention and control
• risk assessment

Objective: To assess the usefulness of the "Candida score" (CS) for discriminating between Candida species colonization and invasive candidiasis (IC) in non-neutropenic critically ill patients. A rate of IC <5% in patents with CS <3 was the primary end point.
Design: Prospective, cohort, observational study.
Patients: A total of 1,107 non-neutropenic adult intensive care unit patients admitted for at least 7 days between April 2006 and June 2007.
Measurements and Main Results: Clinical data, surveillance cultures for fungal growth, and serum levels of (1-3)-beta-D-glucan and anti-Candida antibodies (in a subset of patients) were recorded. The CS was calculated as follows (variables coded as absent = 0, present = 1): total parenteral nutrition x 1, plus surgery x 1, plus multifocal Candida colonization x 1, plus severe sepsis x 2. A CS >= 3 accurately selected patients at high risk for IC. The colonization index was registered if >= 0.5. The rate of IC was 2.3% (95% confidence interval [CI] 1.06-3.54) among patients with CS <3, with a linear association between increasing values of CS and IC rate (p <= 0.001). The area under the receiver operating characteristic curve for CS was 0.774 (95% CI 0.715-0.832) compared with 0.633 (95% CI 0.557-0.709) for CI. (1-3)-Beta-D-glucan was also an independent predictor of IC (odds ratio 1.004, 95% CI 1.0-1.007). The relative risk for developing IC in colonized patients without antifungal treatment was 6.83 (95% CI 3.81-12.45).
Conclusions: In this cohort of colonized patients staying >7 days, with a CS <3 and not receiving antifungal treatment, the rate of IC was <5%. Therefore, IC is highly improbable if a Candida-colonized non-neutropenic critically ill patient has a CS <3. (Crit Care Med 2009; 37:1624-1633)

• 出版日期2009-5