Age-Specific Determinants of Pulse Wave Velocity among Metabolic Syndrome Components, Inflammatory Markers, and Oxidative Stress

作者：Kim Minkyung; Kim Minjoo; Yoo Hye Jin; Lee Seung Yeon; Lee Sang Hyun; Lee Jong Ho^*

来源：Journal of Atherosclerosis and Thrombosis, 2018, 25(2): 178-185.

DOI：10.5551/jat.39388

• Arterial stiffness
• baPWV
• Metabolic syndrome
• Oxidative stress

Aim: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress.
Methods: A total of 4,318 subjects were divided into 4 groups: 19-34 y (n=687), 35-44 y (n 1,413), 45-54 y (n = 1,384), and 55-79 y (n = 834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured.
Results: There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F-2 alpha (8-epi-PGF(2 alpha)), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19-34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35-44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45-54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55-79 y group.
Conclusions: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.

• 出版日期2018