Autophagy in ethanol-exposed liver disease

作者：Wang Li Ren; Zhu Gui Qi; Shi Ke Qing; Braddock Martin; Zheng Ming Hua^*

来源：Expert Review of Gastroenterology and Hepatology, 2015, 9(8): 1031-1037.

DOI：10.1586/17474124.2015.1052065

• ethanol-induced autophagy
• hepatocyte
• liver disease
• selective autophagy

Ethanol metabolism in hepatocytes causes the generation of reactive oxygen species, endoplasmic reticulum stress and alterations in mitochondrial energy and REDOX metabolism. In ethanol-exposed liver disease, autophagy not only acts as a cleanser to remove damaged organelles and cytosolic components, but also selectively clears specific targets such as lipid droplets and damaged mitochondria. Moreover, ethanol appears to play a role in protecting hepatocytes from apoptosis at certain concentrations. This article describes the evidence, function and potential mechanism of autophagy in ethanol-exposed liver disease and the controversy surrounding the effects of ethanol on autophagy.

• 出版日期2015-8
• 单位温州医科大学