Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia

作者：Han, Zhu-Zhen; Zu, Xian-Peng; Wang, Jin-Xin; Li, Hui-Liang^*; Chen, Bing-Yang; Liu, Qing-Xin; Hu, Xian-Qing; Yan, Zhao-Hui; Zhang, Wei-Dong

来源：Tetrahedron, 2014, 70(4): 962-966.

DOI：10.1016/j.tet.2013.12.005

• Valeriana officinalis var latifolia
• Valerianaceae
• Valeneomerins A, B, C, and D
• Neomerane-type sesquiterpenoids
• Neuroprotective activities

Valeneomerins A-D, two new neomerane-type sesquiterpenoids and two new nor-sesquiterpenoids, were isolated from the roots of Valeriana officinalis var. latifolia. Among them, valeneomerin A (1) was identified as a sesquiterpenoid with an unprecedented 15,3-lactone loop while valeneomerin C (3) and valeneomerin D (4) were determined to be nor-sesquiterpenoids with a new 15-reductive neomeranetype carbon skeleton. Their structures were elucidated by detailed spectroscopic analysis and Cu K alpha X-ray crystallography. Compounds 1, 2, and 4 exhibited significant neuroprotective effects against H2O2 induced oxidative stress in SH-SY5Y cells with viability of 49.8, 40.9, and 44.6% each at 50 mu M, respectively, in contrast to positive control (catechin, 50 mu M) with viability of 32.6%.

• 出版日期2014-1-28
• 单位上海中医药大学; 上海交通大学; 中国人民解放军第二军医大学