Model of high-fat diet-induced obesity associated to insulin resistance and glucose intolerance

作者：White Pollyanna A S; Cercato Luana M; Araujo Jessica M D; Souza Lucas A; Soares Andrea F; Barbosa Ana Paula O; Neto Jose M de R; Marcal Anderson C; Machado Ubiratan F; Camargo Enilton A; Santos Marcio R V; Brito Luciana C^*

来源：Arquivos Brasileiros de Endocrinologia e Metabologia, 2013, 57(5): 339-345.

• Obesity
• high-fat diet
• insulin resistance
• glucose intolerance
• mice

Objective: Validate a model of high-fat diet-induced obesity, of low cost, easy reproducibility, that could express characteristics observed in human, and would enable subsequent therapy proposals. Materials and methods: Sixteen Swiss mice received a standard diet (DP) or high-fat diet (DH) for 10 weeks. Results: Although the DP group had greater water (p < 0.01) and feed (p < 0.001) consumption, the DH group had greater body weight (p < 0.5) and adipose tissue gain (p < 0.001), favoring higher adiposity index (p < 0.001), glucose (p < 0.01), and area under the curve in the insulin (p < 0.001) and glucose (p < 0.01) tolerance tests. Conclusion: A high-fat diet-induced obesity model has been validated, which was also associated with insulin resistance and glucose intolerance after a period of 10 weeks.

• 出版日期2013-7