Analysis of glutathione in the presence of acetaminophen and tyrosine via an amplified electrode with MgO/SWCNTs as a sensor in the hemolyzed erythrocyte

作者：Tahernejad-Javazmi, Fahimeh; Shabani-Nooshabadi, Mehdi^*; Karimi-Maleh, Hassan

来源：Talanta, 2018, 176: 208-213.

DOI：10.1016/j.talanta.2017.08.027

• MgO/SWCNTs
• 2-Chloro-N '-[1-(2,5-dihydroxyphenyl) (methylidene)aniline
• Glutathione
• Acetaminophen
• Tyrosine

In this study, we investigated the effect of adding MgO/SWCNTs and 2-Chloro-N'-[1-(2,5-dihydroxyphenyl) methylidene]aniline (2-CDHPMA) to a carbon paste matrix, which could act as a voltammetric sensor for the analysis of glutathione. The electrocatalytic interaction between 2-CDHPMA and glutathione was used as a factor for the analysis of this biological compound in real samples. In addition, the presence of MgO/SWCNTs can help in increasing the sensitivity of the fabricated sensor and for obtaining a low limit of detection in the analysis of glutathione. When the carbon-paste electrode was amplified with MgO/SWCNTs and 2-CDHPMA (CPE/MgO/SWCNTs/2-CDHPMA), it showed a good selectivity for the analysis of glutathione in the presence of acetaminophen and tyrosine with the separated peak potentials at similar to 280 mV, similar to 570 mV, and similar to 880 mV for the first time. We detected a linear dynamic range between 0.05 and 700.0 mu mol L-1 with the limit of detection set at similar to 10 +/- 0.3 nmol L-1 for the analysis of glutathione by the square-wave voltammetric method. The CPE/MgO/SWCNTs/2-CDHPMA showed a high quality of detection of glutathione in the hemolyzed erythrocyte

• 出版日期2018-1-1