A First Generation Chemoenzymatic Synthesis of (+)-Galanthamine

作者:Banwell Martin G*; Ma Xinghua; Karunaratne Ochitha P; Willis Anthony C
来源:Australian Journal of Chemistry, 2010, 63(10): 1437-1447.
DOI:10.1071/CH10201

摘要

A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the Eschenmoser-Claisen rearrangement reaction.

  • 出版日期2010