A single-group pilot feasibility study of cognitive behavioural therapy in people with multiple sclerosis with depressive symptoms

作者:Chruzander Charlotte*; Gottbereg Kristina; Ytterberg Charlotte; Backenroth Gunnel; Fredrikson Sten; Holmqvist Lotta Widen; Johansson Sverker
来源:Disability and Rehabilitation, 2016, 38(24-26): 2383-2391.
DOI:10.3109/09638288.2015.1130179

摘要

Purpose: The aims were to evaluate (a) the feasibility of face-to-face cognitive behavioural therapy (CBT) in people with MS (PwMS) with depressive symptoms; (b) the feasibility of methods and measurements used; and (c) the outcome of the intervention before the conducting of an equivalence study of comparative methods of face-to-face CBT. Design: A single-group pilot feasibility study. Patients: PwMS (n = 15) with sub-threshold to moderate depressive symptoms, recruited at the Karolinska University Hospital, Stockholm, Sweden. Methods: The intervention consisted of 15-20 sessions of face-to-face CBT. Feasibility outcomes included recruitment rate, recruitment procedure and adverse events. Primary clinical outcome was the Beck Depression Inventory-II (BDI-11). Follow-ups were conducted after 3 weeks and 3 months. An estimated sample size calculation was conducted. Results: The face-to-face CBT intervention, methods and measurements used were feasible. The outcome on BDI-II indicated that face-to-face CBT is an effective method for alleviating subthreshold to moderate depressive symptoms in PwMS. Conclusion: Face-to-face CBT is feasible for use in PwMS aiming at decrease depressive symptoms. For an equivalence study, a screening process for depressive symptoms and two comparative intervention arms including traditional face-to-face CBT and low-intensity face-to-face CBT is recommended. Primary outcomes should include the BDI-II and also assessment of anxiety symptoms.

  • 出版日期2016