Application of oxetane ring opening toward stereoselective synthesis of zincophorin fragment

作者：Yadav Jhillu Singh^*; Gyanchander Eppa; Das Saibal

来源：Tetrahedron Letters, 2014, 55(29): 3996-3998.

DOI：10.1016/j.tetlet.2014.05.020

• Oxetane ring opening
• Desymmetrization protocol
• Tetrahydropyran
• Non-Evans syn aldol
• Ionophores

A stereoselective synthesis of the C1-C11 fragment of zincophorin was achieved by using an intramolecular oxetane ring opening reaction as the key step. The oxetane moiety was synthesized by employing a desymmetrization protocol developed at our group and a non-Evans syn aldol as the key steps toward the synthesis.

• 出版日期2014-7-16