A possible heterozygous advantage in muscular dystrophy

作者:Emery A E H*
来源:SAMJ South African Medical Journal, 2016, 106(6): S65-S66.
DOI:10.7196/SAMJ.2016.v106i6.10998

摘要

In certain autosomal recessive disorders there is suggestive evidence that heterozygous carriers may have some selective advantage over normal homozygotes. These include, for example, cystic fibrosis, Tay-Sachs disease and phenylketonuria. The best example so far, however, is that of significant heterozygous advantage in sickle-cell anaemia with increased resistance to falciparum malaria.

  • 出版日期2016-6

全文