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摘要
AimThe objective was to investigate the correlation between macrophage migration inhibitory factor (MIF) promoter polymorphisms (-794CATT(5-7)) and early-stage cervical cancer (ESCC) and to identify a potential biomarker for ESCC. @@@ MethodsA hospital-based case-control study was performed. The case group contained 250 patients with histologically confirmed ESCC. The control group included 147 healthy women. Polymerase chain reaction-single strand conformation polymorphism was used to genotype polymorphisms of MIF promoter -794CATT(5-7). Enzyme-linked immunosorbent assay was applied to detect serum concentration of MIF. @@@ ResultsThe genotype distribution and allele frequency of MIF-794CATT in the ESCC group were significantly different from those in the control group (P<0.05). The 7-CATT repeat carriers were significantly higher in the ESCC group than those in the control group (P<0.05). The 7-CATT repeat carriers (5/7, 6/7, and 7/7) were associated with ESCC and increased risks of cervical cancer (odds ratio=3.5, 3.0, and 5.6; 95% confidence interval=1.2-10.5, 1.2-7.9, and 1.3-25.3, respectively). Serum concentration of MIF was significantly higher in the ESCC group than in the control group (P<0.05), and it was significantly higher in 7-CATT carriers than in non-7-CATT carriers (P<0.05). Neither polymorphisms of MIF-794 nor serum MIF were associated with lymph node metastases and differentiation (P>0.05). @@@ ConclusionMIF promoter polymorphisms (-794CATT) were correlated with ESCC; and 7-CATT might play a role in ESCC. It could be a potential biomarker for ESCC.
- 出版日期2017-3
- 单位山西医科大学
