A novel approach for assessments of erythrocyte sedimentation rate

作者：Pribush A^*; Hatskelzon L; Meyerstein N

来源：International Journal of Laboratory Hematology, 2011, 33(3): 251-257.

DOI：10.1111/j.1751-553X.2010.01277.x

• Erythrocyte
• sedimentation
• aggregation
• conductivity

P>Introduction:
Previous studies have shown that the dispersed phase of sedimenting blood undergoes dramatic structural changes: Discrete red blood cell (RBC) aggregates formed shortly after a settling tube is filled with blood are combined into a continuous network followed by its collapse via the formation of plasma channels, and finally, the collapsed network is dispersed into individual fragments. Based on this scheme of structural transformation, a novel approach for assessments of erythrocyte sedimentation is suggested.
Methods:
Information about erythrocyte sedimentation is extracted from time records of the blood conductivity measured after a dispersion of RBC network into individual fragments.
Results:
It was found that the sedimentation velocity of RBC network fragments correlates positively with the intensity of attractive intercellular interactions, whereas no effect of hematocrit (Hct) was observed.
Conclusion:
Thus, unlike Westergren erythrocyte sedimentation rate, sedimentation data obtained by the proposed method do not require correction for Hct.

• 出版日期2011-6