A randomized controlled trial of third-trimester routine ultrasound in a non-selected population

作者：Skrastad Ragnhild B^*; Eik Nes Sturla H; Sviggum Oddvar; Johansen Ole J; Salvesen Kjell A; Romundstad Pal R; Blaas Harm Gerd K

来源：Acta Obstetricia et Gynecologica Scandinavica, 2013, 92(12): 1353-1360.

DOI：10.1111/aogs.12249

• Pregnancy
• routine ultrasound
• third trimester
• small-for-gestational-age
• large-for-gestational-age
• intrauterine growth restriction
• perinatal outcome

ObjectiveTo compare detection rates of small-for-gestational-age fetuses, large-for-gestational-age fetuses, congenital anomalies and adverse perinatal outcomes in pregnancies randomized to third-trimester routine ultrasound or ultrasound on clinical indication. %26lt;br%26gt;DesignRandomized controlled trial. %26lt;br%26gt;SettingNational Center for Fetal Medicine in Norway between 1989 and 1992. %26lt;br%26gt;PopulationA total of 6780 pregnancies from a non-selected population. %26lt;br%26gt;MethodsTwo routine ultrasound examinations at 18 and 33weeks were compared with routine ultrasound at 18weeks and ultrasound on clinical indication. Suspected small-for-gestational-age fetuses were followed with serial scans and cardiotocography. Doppler ultrasound was not used. %26lt;br%26gt;Main outcome measuresDetection rates of small-for-gestational-age and large-for-gestational-age fetuses, congenital anomalies and adverse perinatal outcomes. %26lt;br%26gt;ResultsThird trimester routine ultrasound improved detection rates of small-for-gestational-age fetuses from 46 to 80%, but overall perinatal morbidity and mortality remained unchanged. Detection of large-for-gestational-age fetuses increased from 36 to 91%. There was a significant increase of induction of labor and elective cesarean sections due to suspected small-for-gestational-age and a significant decrease of induction of labor and elective cesarean sections due to suspected large-for-gestational-age in the study group; there were no other differences regarding intervention. The detection rate of congenital anomalies was 56%, with no significant difference between the groups. %26lt;br%26gt;ConclusionsRoutine use of third-trimester routine ultrasound increased detection rates of small-for-gestational-age and large-for-gestational-age fetuses. This did not alter perinatal outcomes. Third-trimester ultrasound screening should not be rejected before a policy of adding Doppler surveillance to the high-risk group identified has been investigated further.

• 出版日期2013-12