Apoptotic-Related Protein Changes Induced by Hexavalent Chromium in Mice Liver

作者：Wang, Xiao-Feng; Lou, Xiao-Ming; Shen, Ying; Xing, Ming-Luan; Xu, Li-Hong^*

来源：Environmental Toxicology, 2010, 25(1): 77-82.

DOI：10.1002/tox.20478

• Cr(VI)
• apoptosis
• p53
• Bcl-2
• Bax
• cytochrome c
• caspase-3
• in vivo

Although it has been reported that hexavalent chromium (Cr(VI)) could induce apoptosis in a variety of cell types, the molecular mechanisms underlying this process is still largely unknown. This study was undertaken to determine effects of single oral 0, 25, 50, and 100 mg/kg body weight doses of potassium dichromate on the expression level of p53, Bcl-2, Bax, cytochrome c, and caspase-3, which are vital regulators of apoptosis, in mice liver. The results showed that Cr(VI) could upregulate the protein expression of p53, Bax, cytochrome c, and caspase-3 and downregulate the expression of Bcl-2 in mice liver. All these results suggested that p53, Bcl-2, Bax, cytochrome c, and caspase-3 may be involved in the regulation of Cr(VI) induced apoptosis in vivo.

• 出版日期2010-2
• 单位浙江省疾病预防控制中心; 浙江大学