Involvement of nitric oxide in long-term potentiation of spinal nociceptive responses in rats

作者：Zhang XC; Zhang YQ; Zhao ZQ^*

来源：NeuroReport, 2005, 16(11): 1197-1201.

DOI：10.1097/00001756-200508010-00013

• field potentials
• long-term potentiation
• nitric oxide
• spinal cord
• thermal hyperalgesia

Nitric oxide plays an important role in spinal nociception. The present study explored the effects of nitric oxide on the spinal long-term potentiation associated with nociception. (1) Nitric oxide synthase inhibitor L-NAME (I mM, 20 mu l) and the nitric oxide scavenger hemoglobin (2 mg/ml, 20 mu l) strikingly blocked the induction of tetanic sciatic stimulation-induced spinal long-term potentiation of C-fiber-evoked field potentials. L-arginine, a substrate of nitric oxide synthase, completely reversed L-NAME-induced inhibition. However, D-NAME (I mM, 20 mu l), an inactive form of L-NAME, had little effect on the spinal LTR (2) The same tetanic sciatic stimulation induced long-term thermal hyperalgesia, which was blocked by pre-application of L-NAME. These results suggest the involvement of nitric oxide in the spinal long-term potentiation of C-fiber-evoked field potentials and related behavior changes.

• 出版日期2005-8-1
• 单位复旦大学