Morphometry-based measurements of the structural response to whole-brain radiation

作者：Fuentes D^*; Contreras J; Yu J; He R; Castillo E; Castillo R; Guerrero T

来源：International Journal of Computer Assisted Radiology and Surgery, 2015, 10(4): 393-401.

DOI：10.1007/s11548-014-1128-3

• Image registration
• Radiation therapy response
• Morphometry
• Diffeomorphism
• Computational anatomy

Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.
Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures.
An average cerebral volume atrophy of 0.2 and 3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively.
The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.

• 出版日期2015-4