Differential Regulation of IgG-NMO Autoantibodies on S100Beta Protein and Disability in Relapsing Neuromyelitis Optica

作者：Robinson Agramonte Maria A^*; Saravia Goncalves Carlos Alberto; Portela Valmor L; Saiz Hinarejos A; Oses Pierre J; Motta Souza L; Muller A Pastoris; Marquez Gonzalez M E; Gomes de Souza Onofre D

来源：Neuroimmunomodulation, 2010, 17(3): 177-179.

DOI：10.1159/000258717

• Neuromyelitis optica
• Aquaporin 4
• Devic's disease
• S-100beta
• Glial cell markers
• Demyelinating diseases

Neuromyelitis optica (NMO), an uncommon central nervous system (CNS) demyelinating disease, produces transverse myelitis and severe optic neuritis. IgG-NMO autoantibody, a specific immunoglobulin binding aquaporin-4 water channel protein, confirms that NMO is a different entity to multiple sclerosis. Parallel to cytokine down-regulations found in serum of relapsing-NMO (rNMO) patients, it has been reported that IgG-NMO may also confer a worse course of the disease in r-NMO Caribbean patients. In this study, we were interested in exploring the influence of IgG-NMO autoantibody on S100 beta levels and clinical parameters from serum of r-NMO patients. Serum samples from 24 rNMO patients and 10 controls were evaluated. The reduction of S100 beta observed in r-NMO patients was not significant compared to controls; and no differences were present regarding IgG-NMO immunoreactivity. At the same time, a significant correlation was also observed between IgG-NMO autoantibody serum detection and EDSS (Expanded Disability Status Scale) in rNMO. These results corroborate a differential regulation of IgG-NMO autoantibodies on the S100 beta glial marker and on the disability present in rNMO patients.

• 出版日期2010