Antinuclear Antibodies and Clinical Associations in a British Cohort with Limited Cutaneous Systemic Sclerosis

作者：Gliddon Angela E; Dore Caroline J; Dunphy Juliet; Betteridge Zoe; McHugh Neil J; Maddison Peter J^*

来源：Journal of Rheumatology, 2011, 38(4): 702-705.

DOI：10.3899/jrheum.100754

• SCLERODERMA
• LIMITED CUTANEOUS SYSTEMIC SCLEROSIS
• AUTOANTIBODIES

Objective. To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (IcSSc).
Methods. Sera from 180 patients with IcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies.
Results. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at IcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis.
Conclusion. The majority of patients with IcSSc belong to distinctive serologic subsets, potentially with prognostic significance. (First Release Jan 15 2011; J Rheumatol 2011;38:702-5; doi:10.3899/jrheum.100754)

• 出版日期2011-4