Association of the BDNFC270T polymorphism with schizophrenia: Updated meta-analysis

作者：Watanabe Yuichiro^*; Nunokawa Ayako; Someya Toshiyuki

来源：Psychiatry and Clinical Neurosciences, 2013, 67(2): 123-125.

DOI：10.1111/pcn.12018

• brain-derived neurotrophic factor
• meta-analysis
• schizophrenia

Brain-derived neurotrophic factor (BDNF) has been suggested to play a role in the pathophysiology of schizophrenia. The C270T polymorphism (rs56164415) in the BDNF 5-non-coding region has been extensively investigated for an association with schizophrenia, but with conflicting results. An updated meta-analysis was therefore performed of 13 casecontrol association studies (3505 patients and 3992 controls). An association was found between the T allele and schizophrenia. The association was significant in the East Asian population, but not in the Caucasian population. It is suggested that the BDNF C270T polymorphism contributes to schizophrenia susceptibility, especially in East Asian subjects.

• 出版日期2013-2