Adenocarcinoma of the appendix with extra-appendicular spread: Clinico-surgical and histologic analysis of 27 cases

作者：Morera Ocon Francisco J; Camps Vilata Bruno; Munoz Forner Elena; Navarro Campoy Clara; Gallego Plazas Javier; Navarro Fos Samuel

来源：Medicina Clinica, 2017, 149(4): 153-156.

DOI：10.1016/j.medcli.2017.03.031

• Pseudomixoma peritonei
• Appendicular neoplasia
• Mucinous adenocarcinoma
• Peritoneal carcinomatosis
• Hyperthermic intraperitoneal
• chemotherapy

Background and objectives: Appendiceal neoplasms with extra-appendiceal spread may show different clinical patterns with pseudomyxoma peritonei (PMP) being one of them. We analyse the results in a series of patients treated in our centre.
Material and methods: Retrospective study of patients operated on for appendiceal peritoneal carcinomatosis from January 2012 to May 2015.
Results: Twenty-seven consecutive patients were included. Median age 63 years (26-73); 14 were men. Peritoneal carcinomatosis index = 16 +/- 8 (3-31). The suspected preoperative origins were appendix in 23, ovary in 3 and urothelial in one. Postoperative mortality in 2 patients (7.4%).The remaining 36% presented morbidity. Major morbidity (Clavien-Dindo grades 3 and 4) occurred in 3 patients (12%).
Conclusions: Mucinous adenocarcinomas with extra-appendiceal spread may present as PMP with mucinous ascites, jelly-nodular carcinomatosis without ascites, nodular or desmoplasic plates carcinomatosis without jelly mass/nodules. Histology is not correlated to clinical picture. Preoperative diagnosis of mucinous ovarian cancer in peritoneal carcinomatosis scenario may increase the doubt of their ovarian origin and force an appendiceal origin to be ruled out.

• 出版日期2017-8-22