Unique TCR beta-subunit variable gene haplotypes in Africans

作者：Donaldson IJ; Shefta J; Lawson CA; Bushnell JR; Morgan AW; Isaacs JD; Carpenter D; Shaw MA; Rooth I; Quinnell RJ; Zumla AM; Ollier WER; Chintu CZ; Muyinda GP; Hill **S; Boylston AW^*

来源：Immunogenetics, 2002, 53(10-11): 884-893.

DOI：10.1007/s00251-001-0406-8

• T-cell antigen receptor
• haplotype
• African
• malaria
• gradient

This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor -subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5' linkage group, and BV8S3, BV24SI, BV25SI, BV18SI, BV2SI, BV15SI and BV3SI in a 3' link-age group. These loci have been genotyped in individuals from five regions in Africa, including The Gambia, Nigeria, Cameroon, Tanzania, and Zambia, and in individuals from northern Britain, northern India, and Papua New Guinea (PNG). In the 3' linkage group, 11 unique haplotypes were identified in the combined African populations; two equally frequent haplotypes represent the majority of African chromosomes. One haplotype was found in all four regions studied. This is the most frequent haplotype in the northern British, northern Indian and PNG populations. Although present, it is infrequent in the African populations. A North-South gradient in the frequency of a common African haplotype was observed. The distribution did not represent that of a known disease. Evidence suggests that malaria is not responsible for selection of these haplotypes. Overall, this study highlights large differences in the genetic constitution of L the TCRB locus between Africans and other populations.

• 出版日期2002-2