A new triphenylamine fluorescent dye for sensing of cyanide anion in living cell

作者:Qu, Yi; Jin, Bin; Liu, Yi; Wu, Yongquan; Yang, Lin; Wu, Junchen*; Hua, Jianli
来源:Tetrahedron Letters, 2013, 54(36): 4942-4944.
DOI:10.1016/j.tetlet.2013.07.011

摘要

A triphenylamine-based fluorescent probe 1 with larger Stokes shift (similar to 141 nm) has been synthesized, which can make an efficient nucleophilic addition by reacting with CN- in water. Upon addition of CN-, the red fluorescence of 1 was distinctly quenched. Importantly, 1 exhibits a highly selective response toward CN- over other anions in water and a high sensitivity (detection limit <= 11 nM). More-over, it has potential application to track CN- levels in living cells by confocal laser scanning microscopy (CLSM).