Naturally occurring autoantibodies interfere with beta-amyloid metabolism and improve cognition in a transgenic mouse model of Alzheimer's disease 24 h after single treatment

作者：Mengel D; Roeskam S; Neff F; Balakrishnan K; Deuster O; Gold M; Oertel W H; Bacher M; Bach J P; Dodel R^*

来源：Translational Psychiatry, 2013, 3(3): e236.

DOI：10.1038/tp.2012.151

• Alzheimer's disease
• beta-amyloid
• behavior
• inflammation
• natural occurring autoantibodies
• toxic oligomers

There is evidence that naturally occurring antibodies directed against A beta (nAbs-A beta) have a role in A beta-metabolism and A beta-clearance. The presence of nAbs-A beta leads to a reduction in amyloid fibrillation and thus a reduction in their toxicity. We investigated the effects of nAbs-A beta in respect to oligomerization and used the Tg2576 transgenic mouse model in order to investigate the rapid effect with a single-dose (24 h) on oligomer breakdown and cytokine secretion along with immunohistochemical characterization of synaptic plasticity. nAbs-A beta were able to reduce toxic oligomer concentration with an increase in A beta-monomers. Cytokine secretion was significantly reduced. Synaptic plasticity was also improved after administration of nAbs. Finally, single treatment lead to a significant improvement in cognition. This study demonstrates the efficacy of nAbs-A beta and presents evidence that several hallmarks of the disease are targeted by nAbs-A beta.

• 出版日期2013-3