Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts

作者：Tashiro Haruko; Mizutani Noguchi Mitsuho; Shirasaki Ryosuke; Shirafuji Naoki^*

来源：Biochemical and Biophysical Research Communications, 2010, 391(1): 592-597.

DOI：10.1016/j.bbrc.2009.11.104

• MLL
• ELL
• Myofibroblast
• CD133
• Cancer stem cell

Bone marrow-myofibroblasts, a major component of bone marrow-stroma, are reported to originate from hematopoietic stem cells We show in this paper that non-adherent leukemia blasts can change into myofibroblasts When myeloblasts from two cases of acute myelogenous leukemia with a fusion product comprising mixed lineage leukemia and RNA polymerase II elongation factor, were Cultured long term, their morphology changed to that of myofibroblasts with similar molecular characteristics to the parental myeloblasts The original leukemia

• 出版日期2010-1-1