Asymmetric reduction of prochiral ketones with borane using chiral squaric amino alcohols derived from camphor as catalysts

作者：Zou HH; Hu J; Zhang J; You JS; Ma D; Lu D; Xie RG^*

来源：Journal of Molecular Catalysis A: Chemical , 2005, 242(1-2): 57-61.

DOI：10.1016/j.molcata.2005.07.020

• camphor
• squaric acid
• borane
• ketone
• asymmetric reduction

A series of new chiral squaric amino alcohols derived from (R)-(+)-camphor and squaric acid were synthesized, and applied to the enantioselective reduction of prochiral ketones with borane to give secondary alcohols with excellent enantiomeric excesses (up to 99%).

• 出版日期2005-12-1
• 单位四川大学