Functionalization of pyridyl ketones using deprotolithiation-in situ zincation

作者：Hedidi Madani; Erb William^*; Lassagne Frederic; Halauko Yury S^*; Ivashkevich Oleg A; Matulis Vadim E; Roisnel Thierry; Bentabed Ababsa Ghenia^*; Mongin Florence

来源：RSC Advances, 2016, 6(68): 63185-63189.

DOI：10.1039/c6ra11370b

The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl2 center dot TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological interest.

• 出版日期2016
• 单位UNESCO