科研之友
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摘要
A highly stereoselective one-pot procedure involving an enantio-selective Michael addition promoted by low loading of an amino-squaramide catalyst followed by an achiral base catalyzed domino Michael-Knoevenagel-type 1,2-addition sequence provides efficient access to fully substituted cyclohexanes bearing five contiguous stereogenic centers in good yields (68-86%) and excellent stereoselectivities (>30: 1 dr and 96-99% ee).
- 出版日期2014
