Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China

作者：Hao Ying; Wu Bao-gang; Shi Jin; Chen Yan-li; Sun Zhao-qing; Zheng Li-qiang; Zhang Xin-gang; Geng Ning; Li Tie-jun; Li Hong; Sun Ying-xian^*

来源：Chinese Medical Journal, 2011, 124(14): 2113-2116.

DOI：10.3760/cma.j.issn.0366-6999.2011.14.006

• hypertension
• Han Chinese
• GPx-3 gene
• association

Background Genetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase (GPx-3) tag single nucleotide polymorphisms (SNPs) are associated with hypertension in the rural areas of Fuxin county, Liaoning province, China. @@@ Methods Indigenous Fuxin Han people participated, 523 unrelated hypertensives and 547 controls were recruited. All tag SNPs of GPx-3 gene were selected. We estimated SNP allele frequency in DNA pools with pyrosequencing. @@@ Results Before Bonferroni correction, C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls (23.4% vs. 19.3%, P=0.014); T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls (35.6% vs. 40.8%, P=0.009). However, when a Bonferroni correction for multiple testing was applied, only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension (P=0.045, OR: 0.833, 95% Cl: 0.695-0.998). @@@ Conclusion The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning. Chin Med J 2011;124(14):2113-2116

• 出版日期2011-7-20
• 单位中国医科大学