Assessment of plasma brain-derived neurotrophic factor (BDNF), activity-dependent neurotrophin protein (ADNP) and vasoactive intestinal peptide (VIP) concentrations in treatment-naive humans with multiple sclerosis

作者：Kochanowski Jan; Uchman Dorota; Litwiniuk Anna; Kalisz Malgorzata; Wolinska Witort Ewa; Martynska Lidia; Baranowska Boguslawa; Bik Wojciech^*

来源：Neuroendocrinology Letters, 2015, 36(2): 148-152.

• BDNF
• ADNP
• VIP
• multiple sclerosis

OBJECTIVE: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by coexisting processes of inflammation, demyelination, axonal neurodegeneration and gliosis. Autoimmune processes play a pivotal role in the disease. The immune system may be modulated by neurotrophins and neurotrophin factors. Aim of the study was to assess plasma levels of brain-derived neurotrophic factor (BDNF), activity-dependent neurotrophin protein (ADNP) and vasoactive intestinal peptide (VIP) in treatment-naive humans with newly diagnosed multiple sclerosis. We also elucidated the potential influence of selected inflammatory agents on peripheral concentration of BDNF and ADNP.
MATERIAL AND METHODS: The study population comprised of 31 untreated patients with MS and 36 controls from a single hospital centre. Assessment of BDNF and ADNP was performed with use of ELISA methods. VIP was measured with RIA. Selected cytokine levels (IL 6, IL 10, and TNF alpha) were evaluated with ELISA tests. Statistical analyses were performed.
RESULTS: We failed to find any significant differences between ADNP, BDNF, VIP, CRP levels and concentration of cytokines between individuals with MS and the controls. No correlation was observed between ADNP, BDNF and VIP as the first parameter and CRP, IL 6, IL 10, TNF alpha levels and the Expanded Disability Status Scale score in MS.
CONCLUSIONS: Newly diagnosed, treatment-naive patients with MS have comparable levels of plasma BDNF, ADNP and VIP to those of healthy controls.

• 出版日期2015