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摘要
Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive S(N)2-like oxidative addition of a nickel complex to the electrophilic substrate.
- 出版日期2016-6-29
