Acute copper poisoning in sheep

作者：Bandinelli Marcele Bettim; Pavarini Saulo Petinatti^*; Gomes Danilo Carloto; Bassuino Daniele Mariath; Wurster Fabiana; Wouters Flademir; Farias da Cruz Claudio Estevao; Driemeier David

来源：Ciencia Rural, 2013, 43(10): 1862-1865.

• copper
• acute poisoning
• necrosis hepatic
• sheep
• pathology

Cases of acute copper intoxication in Santa Ines sheep are described. The disease occurred on a farm in Rio Grande do Sul. Three ewes that had recently lambed and that were fed cattle diet became severely ill and died one week after ingestion of a commercial mineral mix for beef cattle. The sheep showed anorexia, lateral and sternal recumbency, fasciculation and muscle stiffness and death. At necropsy from one of these sheep, the main changes were moderate hepatomegaly, prominent hepatic lobular pattern, and multifocal randomly distributed erosions and ulcerations on the abomasal mucosa. Histological evaluation of the liver showed marked centrilobular hepatocellular necrosis; diffuse hepatocyte swelling predominantly in the periportal area, and a few Kupffer cells contained cytoplasmic pigment granules. The diagnosis was based on the clinical history, necropsy and histopathologic findings, and confirmed by the high copper concentrations detected in the liver, feed, and mineral mix samples.

• 出版日期2013-10