Adiponectin induces growth inhibition and apoptosis in cervical cancer HeLa cells

作者：Xie Lianying; Wang Yongjun; Wang Shengyu; Wu Na; Chen Yuqiang^*; Yan Jianghua

来源：Biologia, 2011, 66(4): 712-720.

DOI：10.2478/s11756-011-0063-9

• adiponectin
• adiponectin receptors
• HeLa cell
• proliferation
• apoptosis

Obesity is a known risk factor for postmenopausal cervical cancer. In human, plasma adiponectin (ADPN) levels are inversely associated with obesity. ADPN may influence the pathogenesis of cervical cancer. In this paper, the effects of ADPN on the proliferation of the cervical cancer HeLa cells and its underlying mechanism were studied. We discovered that two ADPN receptors were expressed in HeLa cells and ADPN inhibited the proliferation of HeLa cells. Western-blotting showed that ADPN activated AMP kinase in HeLa cells. Reverse transcriptase-polymerase chain reaction revealed ADPN down-regulated the expression of cell cycle regulators cyclin D1 and c-myc, and induced the expression of p21(WAF1/CIP1) and p53. These results indicate that ADPN inhibits proliferation and induces apoptosis of HeLa cells by altering the expression of cell cycle regulators.

• 出版日期2011-8
• 单位厦门大学