Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling

作者：Liuzzi Anna Rita; Kift Morgan Ann; Lopez Anton Melisa; Friberg Ida M; Zhang Jingjing; Brook Amy C; Roberts Gareth W; Donovan Kieron L; Colmont Chantal S; Toleman Mark A; Bowen Timothy; Johnson David W; Topley Nicholas; Moser Bernhard; Fraser Donald J; Eberl Matthias^*

来源：The Journal of Immunology, 2016, 197(6): 2195-2207.

DOI：10.4049/jimmunol.1600990

The antimicrobial responsiveness and function of unconventional human T cells are poorly understood, with only limited access to relevant specimens from sites of infection. Peritonitis is a common and serious complication in individuals with end-stage kidney disease receiving peritoneal dialysis. By analyzing local and systemic immune responses in peritoneal dialysis patients presenting with acute bacterial peritonitis and monitoring individuals before and during defined infectious episodes, our data show that V gamma 9/V delta 2(+) gamma delta T cells and mucosal-associated invariant T cells accumulate at the site of infection with organisms producing (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and vitamin B-2, respectively. Such unconventional human T cells are major producers of IFN-gamma and TNF-alpha in response to these ligands that are shared by many microbial pathogens and affect the cells lining the peritoneal cavity by triggering local inflammation and inducing tissue remodeling with consequences for peritoneal membrane integrity. Our data uncover a crucial role for V gamma 9/V delta 2 T cells and mucosal-associated invariant T cells in bacterial infection and suggest that they represent a useful predictive marker for important clinical outcomes, which may inform future stratification and patient management. These findings are likely to be applicable to other acute infections where local activation of unconventional T cells contributes to the antimicrobial inflammatory response.

• 出版日期2016-9-15