A deficiency in haem oxygenase-1 induces foetal growth restriction by placental vasculature defects

作者：Wong Ronald J^*; Zhao Hui; Stevenson David K

来源：Acta Paediatrica, 2012, 101(8): 827-834.

DOI：10.1111/j.1651-2227.2012.02729.x

• Haemodynamics
• HO-1 deficiency
• Placentation
• Pre-eclampsia
• Pregnancy complications

Haem oxygenase-1 (HO-1), the rate-limiting enzyme in haem degradation, plays a role in angiogenesis and vasculogenesis and is highly expressed in the placenta. Deficiencies in HO-1 are associated with several pregnancy disorders, such as recurrent miscarriages and pre-eclampsia. The unique combination of tissue protective, smooth muscle relaxing and angiogenesis regulatory properties makes HO-1 a key player in the maintenance of a healthy pregnancy through a direct effect on placental structural and vascular development, thus affecting foetal development. Conclusion: Therefore, we conclude that HO-1 plays an important role in placental vasculature development and a deficiency in HO-1 may contribute to pregnancy complications, such as pre-eclampsia, spontaneous abortions and premature births.

• 出版日期2012-8