科研之友
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摘要
A convenient protocol for the rapid and efficient synthesis of 3-(N-substituted) aminocoumarins is described. The synthetic route developed involves the Pd-catalyzed C-N coupling reaction from readily available 3-bromocoumarin derivatives in the presence of the catalytic system Pd(OAc)(2)/Xantphos. Under these conditions, a series of nucleophiles including amides, sulfonamides. carbamates and functionalized amines, have been successfully reacted to afford the coupling products in fair to good yields.
- 出版日期2007-9-24
