H5PW10V2O40@VOx/SBA-15-NH2 catalyst for the solventless synthesis of 3-substituted indoles

作者：Ghohe Narges Mandizadeh; Tayebee Reza^*; Amini Mostafa M; Osatiashtiani Amin; Isaacs Mark A; Lee Adam F^*

来源：Tetrahedron, 2017, 73(40): 5862-5871.

DOI：10.1016/j.tet.2017.08.030

• Vanadia
• SBA-15
• Heteropolyacid
• 3-Substituted indoles
• Solventless

Functionalization of mesoporous SBA-15 frameworks by transition metal oxides offers a flexible route to fabricate new heterogeneous catalysts. Here, an inorganic-organic hybrid nanoporous catalyst H5PW10V2O40@VOx/SBA-15-NH2, was prepared and utilized as an efficient, eco-friendly, and recyclable catalyst for the one-pot, multi-component synthesis of 3-substituted indoles by indole substitution with aldehydes and malononitrile under solvent-free conditions. Catalysts were prepared by the non-covalent attachment of H5PW10V2O40 to a 3 wt%VOx/SBA-15 nanoporous support through a 3-(triethoxysilyl) propylamine linker. VOxiSBA-15 was prepared by a one-pot hydrothermal synthesis from TEOS and vanadium(V) oxytri-tert-butoxide [VO(O-Bu-t)(3)]. The resulting H5PW10V2O40@VOx/SBA-15-NH2 material was characterized by bulk and surface analysis including N-2 porosimetry, FE-SEM, XRD, XPS, TGADTA, UV Vis and ICP-OES, evidencing retention of the heteropolyacid Keggin structure. H5PW10V2O40@VOx/SBA-15-NH2 exhibits high activity and excellent yields (70-95%) of 3-substituted indoles under mild conditions, with negligible deactivation.

• 出版日期2017-10-5