Phenothiazinium photosensitisers IX. Tetra- and pentacyclic derivatives as photoantimicrobial agents

作者：Wainwright Mark^*; Meegan Katie; Loughran Ciara

来源：Dyes and Pigments, 2011, 91(1): 1-5.

DOI：10.1016/j.dyepig.2011.02.001

• Pentacyclic
• Phenothiazinium
• Photoantimicrobial
• Tetracyclic
• Dimethyl methylene blue
• Methylene blue

Methylene blue derivatives, synthesised as novel photosensitising agents are usually simple auxochromic variations on the lead compound. The current paper represents the initial report on the synthesis and biological testing of a new class of phenothiazinium derivatives, having either one or two tetrahydropyridine rings fused to the phenothiazinium chromophore. The derivatives exhibited extended absorption wavelengths, increased amphiphilic character and much greater photoantimicrobial efficacies compared to methylene blue, some examples being more effective even than dimethyl methylene blue. The high activities of this class of photosensitiser recommend its use in infection control, both locally and in blood product decontamination.

• 出版日期2011-10