Asymmetric Synthesis of beta(2)-Tryptophan Analogues via Friedel-Crafts Alkylation of Indoles with a Chiral Nitroacrylate

作者：Pavlov Nikola; Gilles Pierre; Didierjean Claude; Wenger Emmanuel; Naydenova Emilia; Martinez Jean; Calmes Monique^*

来源：Journal of Organic Chemistry, 2011, 76(15): 6116-6124.

DOI：10.1021/jo200733t

The asymmetric Friedel-Crafts alkylation of various indoles with a chiral nitroacrylate provides optically active beta-tryptophan analogues after reduction of the nitro group and removal of the chiral auxiliary. This reaction generally occurs in good yield and high diastereoselectivity (up to 90:10).

• 出版日期2011-8-5
• 单位北京化工大学