科研之友
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摘要
Background Intravascular ultrasound (IVUS) enables the identification of calcification with more details and quantification of calcification but there is not a proper method to quantify the calcification with IVUS Pres taus IVUS studies used arc or length of calcium respectively to quantify calcification but calcium is deter mined by a combination of arc and length We devised a new method to quantify calcium as arc area (AA) in the present study and AA is two-dimensional and irrelavant to N vessel size Methods and Results We selected 201 patients with stable angina pectoris (SAP) unstable angina pectoris (UAP) or acute myocardial infarction (AMI) who underwent IVUS imaging of a de novo name atherosclerotic lesion conside, red to be the culprit lesion before percutaneous coronary intervention between December 2001 and December 2007 The culprit lesion site for analysis was the 10-mm long segment including the am illest lumen cross-sectional area The arc of each calcium deposit in each image was measured with a protractor centered on the lumen and the length of each calcium deposit was calculated with the number of images containing the calcium deposit minus 1 then multiplying 0 5 mm (the images were 0 5 mm apart) Finally the AA was calculated by arc (degree) multiplying length (mm) The average number of calcium deposits in the culprit lesions of patients with acute myocardial infarction (AMI) was significantly larger than patients with SAP or UAP and the number of calcium deposits of patients with SAP or UAP was almost the same (mean +/- SD, AMI 2 21 +/- 1 98 SAP 115 +/- 1 01 UAP 120 +/- 115 AMI versus SAP or UAP p < 0 0005) Tilt. average AA per calcium deposit was significantly different in culprit lesions of patients with SAP and UAP or AMI the calcium deposits were bigger in SAP than in UAP or AMI, and there were no differences between UAP and AMI (mean +/- SD, SAP 788 6 +/- 767 0 degree x mm UAP 136 6 +/- 189 3 degree x mm, AMI 148 4 +/- 217 1 degree x mm SAP versus UAP or AMI p < 0 0005) The total AA of culprit lesions per patient was greatest in patients with SAP less in patients with AMI and least in patients with UAP (mean SD SAP 903 3 +/- 1018 8 degree x mm AMI 301 1 +/- 401 5 degree x mm UAP 163 9 +/- 279 6 degree x mm SAP versus UAP or AMI p < 0 0005 AMI versus UAP p < 0 01) Conclusions The culprit lesions of patients with SAP AMI or UAP has e greatest less or least calcification burden respectively 1 he culprit lesions of patients with SAP have larger and fewer calcium deposits patients with AMI have smaller and more numerous calcium deposits, and patients with UAP has. e smaller and fewer calcium deposits
- 出版日期2008-11
- 单位天津医科大学; 天津市第一中心医院
