Advances in laboratory testing for thrombophilia

作者：Johnson Nicholas V; Khor Bernard; Van Cott Elizabeth M^*

来源：American Journal of Hematology, 2012, 87(S1): S108-S112.

DOI：10.1002/ajh.23186

Testing for hereditary thrombophilia typically includes tests for activated protein C resistance (APC-R) and/or factor V Leiden, protein C, protein S, antithrombin, and prothrombin G20210A. New options for these assays have become available in recent years, with different advantages and disadvantages among the currently available methods. Potential interferences for each assay type are discussed, including lupus anticoagulants, heparin, warfarin, direct thrombin inhibitors (such as argatroban, dabigatran, hirudin, or bivalirudin), rivaroxaban, factor deficiencies or elevations, factor V Leiden, and specific mutations that the assay(s) might not be able to detect. Causes of acquired deficiencies are also described, as these must be carefully excluded before diagnosing a hereditary deficiency of protein C, protein S, or antithrombin. Am. J. Hematol. 87: S108-S112, 2012.

• 出版日期2012-5