Vitamin D Supplementation and Depression in the Women%26apos;s Health Initiative Calcium and Vitamin D Trial

作者：Bertone Johnson Elizabeth R^*; Powers Sally I; Spangler Leslie; Larson Joseph; Michael Yvonne L; Millen Amy E; Bueche Maria N; Salmoirago Blotcher Elena; Wassertheil Smoller Sylvia; Brunner Robert L; Ockene Ira; Ockene Judith K; Liu Simin; Manson JoAnn E

来源：American Journal of Epidemiology, 2012, 176(1): 1-13.

DOI：10.1093/aje/kwr482

• antidepressive agents
• calcium
• clinical trial
• depression
• dietary supplements
• postmenopause
• vitamin D
• women

While observational studies have suggested that vitamin D deficiency increases risk of depression, few clinical trials have tested whether vitamin D supplementation affects the occurrence of depression symptoms. The authors evaluated the impact of daily supplementation with 400 IU of vitamin D-3 combined with 1,000 mg of elemental calcium on measures of depression in a randomized, double-blinded US trial comprising 36,282 postmenopausal women. The Burnam scale and current use of antidepressant medication were used to assess depressive symptoms at randomization (1995-2000). Two years later, women again reported on their antidepressant use, and 2,263 completed a second Burnam scale. After 2 years, women randomized to receive vitamin D and calcium had an odds ratio for experiencing depressive symptoms (Burnam score %26gt;= 0.06) of 1.16 (95% confidence interval: 0.86, 1.56) compared with women in the placebo group. Supplementation was not associated with antidepressant use (odds ratio = 1.01, 95% confidence interval: 0.92, 1.12) or continuous depressive symptom score. Results stratified by baseline vitamin D and calcium intake, solar irradiance, and other factors were similar. The findings do not support a relation between supplementation with 400 IU/day of vitamin D-3 along with calcium and depression in older women. Additional trials testing higher doses of vitamin D are needed to determine whether this nutrient may help prevent or treat depression.

• 出版日期2012-7-1