Potential role of AQP1 and VEGF in the development of malignant pleural effusion in mice

作者：Zhang, Jing Xuan^*; Xie, C M; Zhu, Z W; Huang, H Y; Zeng, Z L

来源：Medical Oncology, 2012, 29(2): 656-662.

DOI：10.1007/s12032-011-9960-6

• Aquaporin-1
• Vascular endothelial growth factor
• Malignant pleural effusion
• In vivo

Recent studies have revealed the important role of aquaporin-1 (AQP1) in tumor cell migration and angiogenesis. However, the function of AQP1 in malignant pleural effusion has not been well characterized. We established a mouse model to examine the role of AQP1 and vascular endothelial growth factor (VEGF) in the development of malignant pleural effusion. We showed that elevated expressions of AQP1 mRNA and VEGF protein were associated with increased volume of malignant pleural effusion. These results suggest that AQP1 and VEGF play important roles in the development of malignant pleural effusion in mice, which may help us find new strategies for the prevention and treatment of malignant pleural effusion.

• 出版日期2012-6
• 单位中山大学