ANTIPROLIFERATIVE AND ANTIMICROBIAL PROPERTIES OF PURE AND ENCAPSULATED RUTIN

作者：Danciu Corina; Pinzaru Iulia Andreea^*; Dehelean Cristina Adriana; Hancianu Monica; Zupko Istvan; Navolan Dan; Licker Monica; Ghiulai Roxana Maria; Soica Codruta Marinela

来源：Farmacia, 2018, 66(2): 302-308.

• rutin
• cyclodextrin
• antiproliferative
• antimicrobial

Rutin, a polyphenolic natural compound is described in the literature for a wide range of biological activities. The study aims to test the antiproliferative potential and the antibacterial effect for pure rutin and its beta cyclodextrin complexes. On one hand, the antiproliferative assays against A2780 (human ovarian cells), MDA-MB-231 (human breast cancer cells) and SiHa (cervical cancer cells) did not show any substantial inhibition of cell growth. On the other hand, the antimicrobial screening revealed that rutin presents positive effects against: Streptococcus pyogenes, Enterococcus faecalis, Bacillus cereus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli. A decreased, but detectable, activity was noticed for Staphylococcus aureus and Streptococcus pneumoniae. Incorporation in the ramified cyclodextrins had a mixed effect on the antibacterial activity, with increased, constant or decreased effect, depending on the strain. The study concludes that rutin can be reconsiderate as a natural active antibacterial agent, while modulation of its solubility by incorporation in beta-cyclodextrins is debatable depending on the tested strain.

• 出版日期2018-4