Brain Metastasis from Colorectal Cancer: Predictors and Treatment Outcomes

作者：Nozawa Hiroaki^*; Ishihara Soichiro; Kawai Kazushige; Sasaki Kazuhito; Murono Koji; Otani Kensuke; Nishikawa Takeshi; Tanaka Toshiaki; Kiyomatsu Tomomichi; Hata Keisuke; Watanabe Toshiaki

来源：Oncology, 2017, 93(5): 309-314.

DOI：10.1159/000478661

• Colorectal cancer
• Brain metastasis
• Predictive factor
• Prognosis
• Radiation therapy

Objective: Difficulties are associated with the management of brain metastasis (BM), which portends a poor prognosis in the treatment of colorectal cancer (CRC). The aim of the present study was to identify risk factors for BM in CRC and evaluate the outcomes of various treatment modalities. Methods: We retrospectively reviewed data on a total of 2,238 patients with primary CRC who underwent surgical resection at our hospital between 1999 and 2014. Predictive factors for BM and prognostic factors after the diagnosis of BM were examined by univariate and multivariate analyses using Cox proportional hazards models. Results: Three patients (0.1%) had BM at the initial diagnosis, and 23 patients (1.2%) developed metachronous BM during the median follow-up period of 44.6 months. Lung and bone metastases were identified as independent predictive factors for BM. Median survival after the diagnosis of BM was 7.4 months. Stereotactic radiosurgery, administered to 41% of the patients with BM, was associated with a better postdiagnostic survival. Conclusion: CRC patients with metastasis to the lung or bone were at a higher risk of BM. Because the survival is still limited, it is crucial to determine the treatment strategy in consideration of the characteristics of each therapy and quality of life in CRC patients with BM.

• 出版日期2017