Dual responsive dysprosium-doped hydroxyapatite particles and toxicity reduction after functionalization with folic and glucuronic acids

作者：Sanchez Lafarga Ana Karen; Pacheco Moises Fermin P; Gurinov Andrey; Gabriel Ortiz Genaro; Carbajal Arizaga Gregorio Guadalupe

来源：Materials Science and Engineering: C , 2015, 48: 541-547.

DOI：10.1016/j.msec.2014.12.033

• Hydroxyapatite
• MRI contrast agent
• Fluorescence
• Toxicity

The development of probes for biomedical applications demands materials with low toxicity levels besides fluorescence or magnetic properties to be detected by confocal microscopes or MRI resonators. Several drug delivery systems or other biomedical materials prepared with hydroxyapatite have been proposed, however, toxicity effects might arise when the size of particles is nanometric. In this study, hydroxyapatite functionalized with glucuronic or folic acids presented lower oxidative stress, measured from lipoperoxides and nitric oxide indicators in rats than pure hydroxyapatite. In separated experiments, hydroxyapatite was doped with dysprosium cations by coprecipitation producing a single crystal phase with fluorescent properties easily visualized by confocal microscopy when excited at 488 nm. These particles also presented the ability to modify the proton relaxation time in T1 maps collected by magnetic resonance imaging. These modified hydroxyapatite nanoparticles could be candidates to design bimodal probes with low toxicity.

• 出版日期2015-3-1