A facile synthesis, antibacterial activity of pulvinone and its derivatives

作者:Xu, Hai-Wei*; Xu, Chao; Fan, Zi-qi; Zhao, Ling-Jie; Liu, Hong-Min
来源:Bioorganic & Medicinal Chemistry Letters, 2013, 23(3): 737-739.
DOI:10.1016/j.bmcl.2012.11.090

摘要

Pulvinone and several 3-fluoro-4-morpholino substituted pulvinone derivatives were synthesized in five steps from a common precursor, phenyl acetic acid. Most of synthetic morpholine substituted pulvinones showed inhibitory activity against Esherichia coli. For the first time, the inhibition of pulvinone and its derivatives against Gram-negative bacteria was reported.