A new antimicrobial and radical-scavenging glycoside from Paullinia pinnata var. cameroonensis

作者:Lunga, Paul-Keilah; Qin, Xu-Jie; Yang, Xing-Wei; Kuiate, Jules-Roger; Du, Zhi-Zhi*; Gatsing, Donatien
来源:Natural Product Research, 2015, 29(18): 1688-1694.
DOI:10.1080/14786419.2014.996756

摘要

A new glycoside, pinnatoside A (1), together with two known compounds (2 and 3), were isolated from the stems of Paullinia pinnata. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical methods. Compound 1 showed significant antibacterial activity with a minimum inhibitory concentration (MIC) value of 1.56g/mL against Escherichia coli, and 2 displayed significant antibacterial activity with a MIC value of 1.56g/mL against Enterobacter aerogenes and E. coli. Equally, compound 1 exhibited the best radical-scavenging activity (RSa(50)=25.07 +/- 0.49g/mL).