Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media

作者:Rodrigo Ana C; Bromfield Stephen M; Laurini Erik; Posocco Paola; Pricl Sabrina; Smith David K*
来源:Chemical Communications, 2017, 53(47): 6335-6338.
DOI:10.1039/c7cc02990j

摘要

Tuning molecular structures of self-assembling multivalent (SAMul) dendritic cationic lipopeptides controls the self- assembled morphology. In buffer, spherical micelles formed by higher generation systems bind polyanionic heparin better than worm-like micelles formed by lower generation systems. In human serum, the binding of sphericalmicelles to heparin is adversely affected, while worm- like micelles maintain their relative binding ability.

  • 出版日期2017-6-14